PPM1D antibody (AA 1-250)

Catalog No. ABIN6146041

Product Details anti-PPM1D Antibody

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Binding Specificity: AA 1-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPM1D antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPS PRRSLSQPLP PRPSPAALPG GEVSGKGPAV AAREARDPLP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG VNRVVWKRPR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PPM1D (NP_003611.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PPM1D

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Alternative Name: PPM1D (PPM1D Products)

Synonyms: PP2C-DELTA antibody, WIP1 antibody, AV338790 antibody, Wip1 antibody, zgc:103518 antibody, ppm1d antibody, wu:fj44c08 antibody, zgc:55836 antibody, zgc:77316 antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D antibody, protein phosphatase 1D magnesium-dependent, delta isoform antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1D antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Db antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Da antibody, PPM1D antibody, Ppm1d antibody, ppm1db antibody, ppm1d.L antibody, ppm1da antibody

Background: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.,PPM1D,PP2C-DELTA,WIP1,IDDGIP,Cancer,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,G2/M DNA Damage Checkpoint,PPM1D

Molecular Weight: 47 kDa/66 kDa

Gene ID: 8493

UniProt: O15297

Pathways: p53 Signaling, Cell Division Cycle