ROBO4 antibody (AA 848-1007)

Catalog No. ABIN6147063

Product Details anti-ROBO4 Antibody

Target: ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (ROBO4))

Binding Specificity: AA 848-1007

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ROBO4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GVGPKGGVLL CPPRPCLTPT PSEGSLANGW GSASEDNAAS ARASLVSSSD GSFLADAHFA RALAVAVDSF GFGLEPREAD CVFIDASSPP SPRDEIFLTP NLSLPLWEWR PDWLEDMEVS HTQRLGRGMP PWPPDSQISS QRSQLHCRMP KAGASPVDYS

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 848-1007 of human ROBO4 (NP_061928.4).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ROBO4

Target: ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (ROBO4))

Alternative Name: ROBO4 (ROBO4 Products)

Synonyms: ECSM4 antibody, MRB antibody, 1200012D01Rik antibody, AI593217 antibody, sc:d0823 antibody, wu:fa16f09 antibody, roundabout guidance receptor 4 antibody, roundabout, axon guidance receptor, homolog 4 (Drosophila) antibody, ROBO4 antibody, Robo4 antibody, robo4 antibody

Background: Roundabout homolog 4, also known as magic roundabout and ROBO4 is a member of the immunoglobulin superfamily and ROBO family. ROBO4 is specifically expressed in endothelial cells. It is expressed at sites of angiogenesis in different tumor types. ROBO4 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. ROBO4 is the fourth identified member of the roundabout receptor family. It is the only Robo family member expressed in primary endothelial cells and that application of Slit inhibits their migration. ROBO4 is predominantly expressed in embryonic or tumor vascular endothelium and is considered important for vascular development and as a candidate tumor endothelial marker. ROBO4 is a bona fide member of the Robo family and may provide a repulsive cue to migrating endothelial cells during vascular development. ROBO4 is a receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. ROBO4 may mediate the inhibition of primary endothelial cell migration by Slit proteins. Activating ROBO4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.,ROBO4,ECSM4,MRB,Cancer,Invasion and Metastasis,Cell Biology & Developmental Biology,Extracellular Matrix,Neuroscience,Cardiovascular,Angiogenesis,ROBO4

Molecular Weight: 75 kDa/98 kDa/107 kDa

Gene ID: 54538

UniProt: Q8WZ75