SF3B2 antibody (AA 616-895)

Catalog No. ABIN6147666

Product Details anti-SF3B2 Antibody

Target: SF3B2 (Splicing Factor 3b, Subunit 2, 145kDa (SF3B2))

Binding Specificity: AA 616-895

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SF3B2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: SLGMPVGPNA HKVPPPWLIA MQRYGPPPSY PNLKIPGLNS PIPESCSFGY HAGGWGKPPV DETGKPLYGD VFGTNAAEFQ TKTEEEEIDR TPWGELEPSD EESSEEEEEE ESDEDKPDET GFITPADSGL ITPGGFSSVP AGMETPELIE LRKKKIEEAM DGSETPQLFT VLPEKRTATV GGAMMGSTHI YDMSTVMSRK GPAPELQGVE VALAPEELEL DPMAMTQKYE EHVREQQAQV EKEDFSDMVA EHAAKQKQKK RKAQPQDSRG GSKKYKEFKF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 616-895 of human SF3B2 (NP_006833.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SF3B2

Target: SF3B2 (Splicing Factor 3b, Subunit 2, 145kDa (SF3B2))

Alternative Name: SF3B2 (SF3B2 Products)

Synonyms: 145kDa antibody, 2610311M13Rik antibody, 2810441F20Rik antibody, B230398H18Rik antibody, SAP145 antibody, SF3b1 antibody, SF3b145 antibody, SF3b150 antibody, SF3B2 antibody, cus1 antibody, sap145 antibody, sf3b145 antibody, sf3b150 antibody, Cus1 antibody, SF3B145 antibody, splicing factor 3b, subunit 2 antibody, splicing factor 3b subunit 2 antibody, splicing factor 3B subunit 2 antibody, splicing factor 3b subunit 2 L homeolog antibody, Sf3b2 antibody, SF3B2 antibody, LOC714747 antibody, sf3b2.L antibody, sf3b2 antibody

Background: This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus.,SF3B2,Cus1,SAP145,SF3B145,SF3b1,SF3b150,Epigenetics & Nuclear Signaling,RNA Binding,SF3B2

Molecular Weight: 100 kDa

Gene ID: 10992

UniProt: Q13435