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SHARPIN antibody (AA 1-170)

SHARPIN Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6147733
  • Target See all SHARPIN Antibodies
    SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
    Binding Specificity
    • 15
    • 7
    • 6
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-170
    Reactivity
    • 44
    • 24
    • 19
    • 2
    • 1
    • 1
    Human
    Host
    • 41
    • 3
    Rabbit
    Clonality
    • 43
    • 1
    Polyclonal
    Conjugate
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SHARPIN antibody is un-conjugated
    Application
    • 40
    • 18
    • 13
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequence
    MAPPAGGAAA AASDLGSAAV LLAVHAAVRP LGAGPDAEAQ LRRLQLSADP ERPGRFRLEL LGAGPGAVNL EWPLESVSYT IRGPTQHELQ PPPGGPGTLS LHFLNPQEAQ RWAVLVRGAT VEGQNGSKSN SPPALGPEAC PVSLPSPPEA STLKGPPPEA DLPRSPGNLT
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human SHARPIN (NP_112236.3).
    Isotype
    IgG
    Top Product
    Discover our top product SHARPIN Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:100
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
    Alternative Name
    SHARPIN (SHARPIN Products)
    Synonyms
    0610041B22Rik antibody, AW121341 antibody, RBCKL1 antibody, SIPL1 antibody, cpdm antibody, Conneck1 antibody, SHANK-associated RH domain interacting protein antibody, SHANK associated RH domain interactor antibody, SHANK-associated RH domain interactor antibody, Sharpin antibody, SHARPIN antibody
    Background
    Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.,SHARPIN,SIPL1,sharpin,Cell Biology & Developmental Biology,Ubiquitin,SHARPIN
    Molecular Weight
    33 kDa/39 kDa
    Gene ID
    81858
    UniProt
    Q9H0F6
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