SPSB1 antibody (AA 1-60)

Catalog No. ABIN6148398

Product Details anti-SPSB1 Antibody

Target: SPSB1 (SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1))

Binding Specificity: AA 1-60

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPSB1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV QLLHSWNNND

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SPSB1 (NP_079382.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPSB1

Target: SPSB1 (SplA/ryanodine Receptor Domain and SOCS Box Containing 1 (SPSB1))

Alternative Name: SPSB1 (SPSB1 Products)

Synonyms: SSB-1 antibody, SSB1 antibody, 1110014L01Rik antibody, 4930422J18Rik antibody, AI596360 antibody, AI854583 antibody, splA/ryanodine receptor domain and SOCS box containing 1 antibody, SPSB1 antibody, Spsb1 antibody

Background: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.,SPSB1,SSB-1,SSB1,SPSB1

Molecular Weight: 30 kDa

Gene ID: 80176

UniProt: Q96BD6