TGS1 antibody (AA 714-853)
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- Target See all TGS1 Antibodies
- TGS1 (Trimethylguanosine Synthase 1 (TGS1))
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Binding Specificity
- AA 714-853
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TGS1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- RVIAIDIDPV KIALARNNAE VYGIADKIEF ICGDFLLLAS FLKADVVFLS PPWGGPDYAT AETFDIRTMM SPDGFEIFRL SKKITNNIVY FLPRNADIDQ VASLAGPGGQ VEIEQNFLNN KLKTITAYFG DLIRRPASET
- Cross-Reactivity
- Human, Mouse
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 714-853 of human TGS1 (NP_079107.6).
- Isotype
- IgG
- Top Product
- Discover our top product TGS1 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- TGS1 (Trimethylguanosine Synthase 1 (TGS1))
- Alternative Name
- TGS1 (TGS1 Products)
- Synonyms
- NCOA6IP antibody, PIMT antibody, PIPMT antibody, D4Ertd800e antibody, Ncoa6ip antibody, Pimt antibody, trimethylguanosine synthase 1 antibody, trimethylguanosine synthase 1 L homeolog antibody, TGS1 antibody, Tgs1 antibody, tgs1.L antibody
- Background
- Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7G caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7G cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs. Plays a role in transcriptional regulation.,TGS1,NCOA6IP,PIMT,PIPMT,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Nuclear hormone receptors,Cancer,Signal Transduction,TGS1
- Molecular Weight
- 96 kDa
- Gene ID
- 96764
- UniProt
- Q96RS0
- Pathways
- Mitotic G1-G1/S Phases, Regulation of Lipid Metabolism by PPARalpha, Ribonucleoprotein Complex Subunit Organization
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