UGT1A4 antibody (AA 29-150)

Catalog No. ABIN6149897

Product Details anti-UGT1A4 Antibody

Target: UGT1A4 (UDP Glucuronosyltransferase 1 Family, Polypeptide A4 (UGT1A4))

Binding Specificity: AA 29-150

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UGT1A4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GKVLVVPTDG SPWLSMREAL RELHARGHQA VVLTPEVNMH IKEEKFFTLT AYAVPWTQKE FDRVTLGYTQ GFFETEHLLK RYSRSMAIMN NVSLALHRCC VELLHNEALI RHLNATSFDV VL

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 29-150 of human UGT1A4 (NP_009051.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UGT1A4

Target: UGT1A4 (UDP Glucuronosyltransferase 1 Family, Polypeptide A4 (UGT1A4))

Alternative Name: UGT1A4 (UGT1A4 Products)

Background: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.,UGT1A4,HUG-BR2,UDPGT,UDPGT 1-4,UGT-1D,UGT1-04,UGT1.4,UGT1A4S,UGT1D,UDPGT1-4,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Drug metabolism,UGT1A4

Molecular Weight: 49 kDa/60 kDa

Gene ID: 54657

UniProt: P22310

Pathways: Steroid Hormone Biosynthesis, Regulation of Lipid Metabolism by PPARalpha