XPC antibody (AA 700-940)

Catalog No. ABIN6150295

Product Details anti-XPC Antibody

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Binding Specificity: AA 700-940

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Sequence: GEVPYKMVKG FSNRARKARL AEPQLREEND LGLFGYWQTE EYQPPVAVDG KVPRNEFGNV YLFLPSMMPI GCVQLNLPNL HRVARKLDID CVQAITGFDF HGGYSHPVTD GYIVCEEFKD VLLTAWENEQ AVIERKEKEK KEKRALGNWK LLAKGLLIRE RLKRRYGPKS EAAAPHTDAG GGLSSDEEEG TSSQAEAARI LAASWPQNRE DEEKQKLKGG PKKTKREKKA AASHLFPFEQ L

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 700-940 of human XPC (NP_004619.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IP,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-XPC antibody (ABIN6150295)

Gu, Chang, Dai, Song, Zhao, Lei: "Identification of four novel XPC mutations in two xeroderma pigmentosum complementation group C patients and functional study of XPC Q320X mutant." in: Gene, Vol. 628, pp. 162-169, (2017) (PubMed).

Target Details for XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Alternative Name: XPC (XPC Products)

Synonyms: RAD4 antibody, XP3 antibody, XPCC antibody, XPC complex subunit, DNA damage recognition and repair factor antibody, xeroderma pigmentosum, complementation group C antibody, XPC antibody, Xpc antibody

Background: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.,XPC,RAD4,XP3,XPCC,p125,Epigenetics & Nuclear Signaling,DNA Damage & Repair,XPC

Molecular Weight: 15 kDa/101 kDa/105 kDa

Gene ID: 7508

UniProt: Q01831

Pathways: p53 Signaling, DNA Damage Repair