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ZRANB3 antibody (AA 818-1077)

ZRANB3 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6150540
  • Target See all ZRANB3 products
    ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))
    Binding Specificity
    • 5
    • 1
    • 1
    • 1
    AA 818-1077
    Reactivity
    • 9
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 9
    Rabbit
    Clonality
    • 9
    Polyclonal
    Conjugate
    • 5
    • 2
    • 1
    • 1
    This ZRANB3 antibody is un-conjugated
    Application
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    ITKQQTKQNC TKRYITKEDV AVASMDKVKN VGGHVRLITK ESRPRDPFTK KLLEDGACVP FLNPYTVQAD LTVKPSTSKG YLQAVDNEGN PLCLRCQQPT CQTKQACKAN SWDSRFCSLK CQEEFWIRSN NSYLRAKVFE TEHGVCQLCN VNAQELFLRL RDAPKSQRKN LLYATWTSKL PLEQLNEMIR NPGEGHFWQV DHIKPVYGGG GQCSLDNLQT LCTVCHKERT ARQAKERSQV RRQSLASKHG SDITRFLVKK
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 818-1077 of human ZRANB3 (NP_001273497.1).
    Isotype
    IgG
  • Application Notes
    WB,1:1000 - 1:3000
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Margalef, Kotsantis, Borel, Bellelli, Panier, Boulton: "Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe." in: Cell, Vol. 172, Issue 3, pp. 439-453.e14, (2019) (PubMed).

  • Target
    ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))
    Alternative Name
    ZRANB3 (ZRANB3 Products)
    Synonyms
    4933425L19Rik antibody, AH2 antibody, AI316834 antibody, C730006D09 antibody, zinc finger RANBP2-type containing 3 antibody, zinc finger, RAN-binding domain containing 3 antibody, ZRANB3 antibody, Zranb3 antibody
    Background
    DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.,ZRANB3,4933425L19Rik,AH2,Epigenetics & Nuclear Signaling,ZRANB3
    Molecular Weight
    42 kDa/49 kDa/67 kDa/123 kDa
    Gene ID
    84083
    UniProt
    Q5FWF4
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