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APOBEC3G antibody (C-Term)

APOBEC3G Reactivity: Human WB, IHC (p), EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN615432
  • Target See all APOBEC3G Antibodies
    APOBEC3G (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G))
    Binding Specificity
    • 15
    • 13
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 90
    • 3
    • 2
    • 1
    Human
    Host
    • 84
    • 5
    • 1
    Goat
    Clonality
    • 88
    • 2
    Polyclonal
    Conjugate
    • 37
    • 10
    • 9
    • 9
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APOBEC3G antibody is un-conjugated
    Application
    • 84
    • 53
    • 38
    • 14
    • 13
    • 13
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Sequence
    C-DEHSQDLSGR LR
    Specificity
    This antibody detects APOBEC3G (C-term).
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Immunoaffinity Chromatography
    Immunogen
    Synthetic peptide from the C Terminus of the protein sequence according to NP_068594.1
    Top Product
    Discover our top product APOBEC3G Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3, 0.5 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    APOBEC3G (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G))
    Alternative Name
    APOBEC3G (APOBEC3G Products)
    Synonyms
    A3G antibody, ARCD antibody, ARP-9 antibody, ARP9 antibody, CEM-15 antibody, CEM15 antibody, bK150C2.7 antibody, dJ494G10.1 antibody, apolipoprotein B mRNA editing enzyme catalytic subunit 3G antibody, APOBEC3G antibody
    Background
    The Apoliprotein B mRNA-editing, enzyme-catalytic, polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5a which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection as at least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated HIV-1 virions and induce hypermutation in the newly synthesized viral DNA and thus destabilize the viral genome. This innate mechanism of retroviral resistance is counteracted by the HIV-1 Vif protein by inducing the ubiquitization and degradation of APOBEC3G, a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.Synonyms: APOBEC-3G, APOBEC-related cytidine deaminase, ARCD, ARP9, CEM15, DNA dC->dU-editing enzyme APOBEC-3G, MDS019
    Gene ID
    60489
    NCBI Accession
    NP_068594
    UniProt
    Q9HC16
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