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DNASE1 antibody (AA 1-252)

DNASE1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN615834
  • Target See all DNASE1 Antibodies
    DNASE1 (Deoxyribonuclease I (DNASE1))
    Binding Specificity
    • 15
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-252
    Reactivity
    • 60
    • 26
    • 14
    • 12
    Human
    Host
    • 57
    • 12
    • 1
    Rabbit
    Clonality
    • 60
    • 10
    Polyclonal
    Conjugate
    • 33
    • 10
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This DNASE1 antibody is un-conjugated
    Application
    • 57
    • 21
    • 16
    • 13
    • 13
    • 10
    • 8
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody recognizes Deoxyribonuclease I (DNASE1).
    Cross-Reactivity (Details)
    Species reactivity (expected):Rabbit (81 %), Dogs (81 %).
    Species reactivity (tested):Human.
    Purification
    Immunoaffinity Chromatography
    Immunogen
    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 252 of DNase I. Genename: DNASE1
    Top Product
    Discover our top product DNASE1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.0 mg/mL
    Buffer
    0.1 M Tris-glycine, pH 7.0 containing 10 % Glycerol and 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
  • Target
    DNASE1 (Deoxyribonuclease I (DNASE1))
    Alternative Name
    Deoxyribonuclease-1 (DNASE1 Products)
    Synonyms
    LOC397802 antibody, DNL1 antibody, DRNI antibody, AI788650 antibody, DNaseI antibody, Dnl1 antibody, dnase1-A antibody, zgc:92440 antibody, DNase I antibody, deoxyribonuclease 1 antibody, deoxyribonuclease I antibody, deoxyribonuclease I L homeolog antibody, Deoxyribonuclease I antibody, endA antibody, LOC397802 antibody, DNASE1 antibody, Dnase1 antibody, dnase1.L antibody, dnase1 antibody, CpipJ_CPIJ011184 antibody, CpipJ_CPIJ011185 antibody, CpipJ_CPIJ011186 antibody, CpipJ_CPIJ011187 antibody, CpipJ_CPIJ011190 antibody, CpipJ_CPIJ017803 antibody, Desal_1409 antibody, MPET_RS05255 antibody, METEV_RS02275 antibody, Plabr_0631 antibody
    Background
    Deoxyribonuclease I (EC 3.1.21.1) gene is approximately 3.2 kb long with 9 exons separated by 8 introns. In the form of a bovine pancreatic enzyme preparation, it occupies an important place in the history of protein chemistry and enzymology: it was the first enzyme to be recognized as specific for DNA, it was the first DNase to be crystallized, and it was the first DNase for which a specific protein inhibitor was characterized. DNase I is a Ca2+ and Mg2+ dependant endonuclease. DNase I is synthesized in the pancreas and stored in zymogen granules. It has been used to reduce the viscosity of cystic fibrosis sputum. A DNase I-like enzyme appears to catalyze the degradation of chromatin to oligo- and mononucleosomes during apoptosis. A recent study has demonstrated an endonuclease with activity and antigenicity indistinguishable from DNase I in thymocytes, cells susceptible to apoptosis. DNase I is an endonuclease that hydrolyzes double-stranded or single stranded DNA preferentially at sites adjacent to pyrimidine nucleotides. The product of hydrolysis is a complex mixture of 5'-phosphate mononucleotides and oligonucleotides. In the presence of Mg ion, DNase I attacks each strand of DNA independently and the cleavage sites are random.Synonyms: DNASE1, DNL1, DNase I, DRNI, Deoxyribonuclease I
    Gene ID
    1773
    NCBI Accession
    NP_005214
    UniProt
    P24855
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