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Tryptophan Hydroxylase 2 antibody (Internal Region)

TPH2 Reactivity: Human, Dog IHC (p), EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN615872
  • Target See all Tryptophan Hydroxylase 2 (TPH2) Antibodies
    Tryptophan Hydroxylase 2 (TPH2)
    Binding Specificity
    • 26
    • 8
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 52
    • 39
    • 28
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    Human, Dog
    Host
    • 63
    • 6
    • 3
    Goat
    Clonality
    • 66
    • 6
    Polyclonal
    Conjugate
    • 39
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This Tryptophan Hydroxylase 2 antibody is un-conjugated
    Application
    • 53
    • 30
    • 24
    • 13
    • 13
    • 13
    • 8
    • 7
    • 3
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Sequence
    C-NKPNSGKNDD KGNK
    Specificity
    Recognizes Tryptophan hydroxylase 2 / TPH2
    Cross-Reactivity (Details)
    Species reactivity (expected):Canine (Dog).
    Species reactivity (tested):Human.
    Purification
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
    Immunogen
    Peptide with sequence from the internal region of the protein sequence according to NP_775489.2.
    Top Product
    Discover our top product TPH2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Tryptophan Hydroxylase 2 (TPH2)
    Alternative Name
    Tryptophan 5-Hydroxylase 2 (TPH2) (TPH2 Products)
    Synonyms
    ADHD7 antibody, NTPH antibody, Ntph antibody, tphR antibody, wu:fq15a04 antibody, AU043594 antibody, tryptophan hydroxylase 2 antibody, tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) antibody, TPH2 antibody, Tph2 antibody, tph2 antibody
    Background
    Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II) (Jiang et al., 2000, Johansen et al., 1996). CaM K II phosphorylates Ser19 which lies within the regulatory domain of TPH2 (McKinney et al., 2005).Synonyms: NTPH, Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2
    Gene ID
    121278
    NCBI Accession
    NP_775489
    UniProt
    Q8IWU9
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