EIF2S2 antibody (pSer2)

Catalog No. ABIN616039

Product Details anti-EIF2S2 Antibody

Target: EIF2S2 (Eukaryotic Translation Initiation Factor 2, Subunit 2 Beta, 38kDa (EIF2S2))

Binding Specificity: pSer2

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF2S2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: M-S(p)-G-D-E

Specificity: This antibody detects endogenous levels of eIF2β only when phosphorylated at serine 2.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around phosphorylation site of serine 2 derived from eIF2beta.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for EIF2S2

Target: EIF2S2 (Eukaryotic Translation Initiation Factor 2, Subunit 2 Beta, 38kDa (EIF2S2))

Alternative Name: EIF2B / EIF2S2 (EIF2S2 Products)

Synonyms: EIF2 antibody, EIF2B antibody, EIF2beta antibody, PPP1R67 antibody, eIF-2-beta antibody, 2810026E11Rik antibody, 38kDa antibody, AA408636 antibody, AA571381 antibody, AA986487 antibody, AW822225 antibody, D2Ertd303e antibody, zgc:77084 antibody, wu:fc26g03 antibody, wu:fu10f07 antibody, MGC130959 antibody, DDBDRAFT_0205105 antibody, DDBDRAFT_0234112 antibody, DDB_0205105 antibody, DDB_0234112 antibody, AO090005001412 antibody, eukaryotic translation initiation factor 2 subunit beta antibody, eukaryotic translation initiation factor 2, subunit 2 (beta) antibody, eukaryotic translation initiation factor 2, subunit 2 beta antibody, eukaryotic translation initiation factor 2 subunit beta L homeolog antibody, eIF-3 beta antibody, hypothetical protein antibody, eukaryotic translation initiation factor 2 subunit 2 antibody, EIF2S2 antibody, Eif2s2 antibody, eif2s2 antibody, eif2s2.L antibody, eIF2s2 antibody, TP02_0678 antibody, EDI_093670 antibody, AOR_1_2450174 antibody, MGYG_05853 antibody, PGTG_10708 antibody, LOC101111733 antibody

Background: EIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.Synonyms: Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit beta, eIF-2-beta, eIF2-beta

Molecular Weight: 38 kDa

Gene ID: 8894

NCBI Accession: NP_003899

UniProt: P20042