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UACA antibody

UACA Reactivity: Human, Mouse WB, IF, FACS Host: Mouse Monoclonal AE-5 unconjugated
Catalog No. ABIN6168044
  • Target See all UACA Antibodies
    UACA
    Reactivity
    • 42
    • 16
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 28
    • 14
    Mouse
    Clonality
    • 30
    • 12
    Monoclonal
    Conjugate
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UACA antibody is un-conjugated
    Application
    • 36
    • 14
    • 13
    • 13
    • 11
    • 8
    • 7
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
    Purpose
    Mouse Monoclonal anti-UACA / Nucling (AE-5), Purified, BSA-free
    Characteristics
    UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Purification
    Purified
    Immunogen
    Nuclei of myeloid leukemia biopsy cells
    Clone
    AE-5
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product UACA Primary Antibody
  • Application Notes
    Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Immunofluorescence 0.5-1.0 μg/mL
    • Western blotting 0.5-1 μg/mL
    • Optimal dilution for a specific application should be determined by user
    Comment

    HeLa or 293T cells. Highly expressed in skeletal muscle, heart, kidney and pancreas. Also expressed in epidermal melanocytes, eye muscles and thyroid follicular cells.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS (no BSA, no azide)
    Preservative
    Azide free
  • Target
    UACA
    Alternative Name
    UACA / Nucling (UACA Products)
    Synonyms
    NUCLING antibody, 2700059D02Rik antibody, nucling antibody, RGD1560011 antibody, uveal autoantigen with coiled-coil domains and ankyrin repeats antibody, UACA antibody, Uaca antibody
    Background
    Nuclear membrane binding protein, Uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA), NUCLING
    Molecular Weight
    160 kDa
    Gene ID
    55075, 108049
    UniProt
    Q9BZF9
    Pathways
    Positive Regulation of Endopeptidase Activity
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