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Complement C4d antibody (Complement Component C4d) (CF®555) Primary Antibody

C4d Reactivity: Human Coat, ELISA, IF Host: Mouse Monoclonal C4D203 CF®555
Catalog No. ABIN6173776
$270.77
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  • Target See all Complement C4d (C4d) Antibodies
    Complement C4d (C4d)
    Reactivity
    • 53
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 45
    • 8
    Mouse
    Clonality
    • 46
    • 7
    Monoclonal
    Conjugate
    • 23
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This Complement C4d antibody is conjugated to CF®555
    Application
    • 40
    • 40
    • 31
    • 16
    • 12
    • 11
    • 7
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Coating (Coat), ELISA, Immunofluorescence (IF)
    Purpose
    Mouse Monoclonal anti-Complement C4d (C4D203), CF555 Conjugate
    Characteristics
    This MAb is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 Molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    Immunogen
    Recombinant human Complement 4d protein
    Clone
    C4D203
    Isotype
    IgG1
  • Application Notes
    Immunofluorescence 0.5-1.0 μg/mL
    • ELISA For coating use Ab at 1-2 μg/mL, order Ab without BSA
    • Optimal dilution for a specific application should be determined by user
    Comment

    Rejected Renal Transplant Tissue

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    100 μg/mL
    Buffer
    PBS/0.1 % BSA/0.05 % azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from light
  • Target
    Complement C4d (C4d)
    Abstract
    C4d Products
    Molecular Weight
    192 kDa (predicted)
    Gene ID
    720, 721
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