Insulin antibody (INS)

Details for Product anti-INS Antibody No. ABIN617877, Supplier: Log in to see
Antigen
  • ins1
  • xins
  • ins1-a
  • Insulin
  • IDDM2
  • ILPR
  • IRDN
  • MODY10
  • AA986540
  • Ins-2
  • InsII
  • Mody
  • Mody4
  • proinsulin
  • zgc:109842
  • insulin
  • insulin precursor
  • insulin II
  • preproinsulin
  • ins
  • PIN
  • INS
  • Ins
  • INS-IGF2
  • Ins2
Alternatives
anti-Human Insulin antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Buffalo (Bubalus), Chicken, Cow (Bovine), Horse (Equine), Human, Lizard, Macaque, Monkey, Moth, Mouse (Murine), Pig (Porcine), Rat (Rattus), Sheep (Ovine)
951
469
369
349
239
194
45
11
9
7
7
6
5
3
2
2
2
2
2
2
1
1
1
Host
Rabbit
786
196
50
9
4
2
1
Clonality
Polyclonal
Conjugate
This Insulin antibody is un-conjugated
52
41
36
21
20
20
20
15
15
15
13
13
13
13
13
13
13
10
9
9
7
7
7
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
5
2
1
Application
Immunoelectron Microscopy (IEM), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
462
358
276
269
258
238
181
117
106
67
66
31
26
23
21
8
7
6
5
4
4
3
2
2
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Insulin
Isotype IgG
Cross-Reactivity Cow (Bovine), Pig (Porcine), Rat (Rattus)
Characteristics The Insulin antiserum was quality control tested using standard immunohistochemical methods. The antiserum demonstrates strongly positive labeling of rat pancreatic beta cells using indirect immunofluorescent and biotin/avidin-HRP techniques. Recommended primary dilutions for these methods are 1/500-1/1000 in PBS/0.3 % Triton X-100 - Cy3 Technique and 1/3000-1/5000 in PBS/0.3 % Triton X-100 - biotin/avidin-HRP Technique. Immuostaining is completely abolished by soluble pre-adsorption with bovine insulin at 10 μg per mL of diluted antiserum.
Purification Whole Serum
Plasmids, Primers & others Plasmids, Primers & others Insulin products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Insulin (INS Antibody Abstract)
Gene ID 397415, 280829
Pathways NF-kappaB Signaling, RTK Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
Restrictions For Research Use only
Format Liquid
Buffer Contains ≤ 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment After reconstitution, use immediately or refrigerate at 2 - 8 °C up to 2 days. For long-term storage aliquot antibody and freeze at -15 °C or lower. Avoid repeated freeze/thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-Insulin (INS) antibody (ABIN617877) IHC image of beta cells in islets of Langerhans of rat pancreas
Product cited in: Nicol, Grant, Grant, Comstock, Nguyen, Smith, Grove, Marks: "Pancreatic inflammation and increased islet macrophages in insulin-resistant juvenile primates." in: The Journal of endocrinology, Vol. 217, Issue 2, pp. 207-13, 2013 (PubMed).

Jung, Jung, Ramalingam, Yoon, Bae, Park: "Anti-diabetic effect of Wen-pi-tang-Hab-Wu-ling-san extract in streptozotocin-induced diabetic rats." in: Indian journal of pharmacology, Vol. 44, Issue 1, pp. 97-102, 2012 (PubMed).

Hasegawa, Fukui, Hosoda, Asano, Harusato, Tanaka, Shiraishi, Senmaru, Sakabe, Yamasaki, Kitawaki, Fujinami, Ohta, Obayashi, Nakamura: "Telmisartan, an angiotensin II type 1 receptor blocker, prevents the development of diabetes in male Spontaneously Diabetic Torii rats." in: European journal of pharmacology, Vol. 605, Issue 1-3, pp. 164-9, 2009 (PubMed).

Ravassard, Emilie Bricout-Neveu, Hazhouz, Pechberty, Mallet, Czernichow, Scharfmann: "A new strategy to generate functional insulin-producing cell lines by somatic gene transfer into pancreatic progenitors." in: PLoS ONE, Vol. 4, Issue 3, pp. e4731, 2009 (PubMed).

Du, Klimstra, Varmus: "Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors." in: PLoS ONE, Vol. 4, Issue 9, pp. e6932, 2009 (PubMed).

Danilova, Tai, Mele, Beinborn, Leiter, Greenberg, Perfield, Defuria, Singru, Lechan, Huber: "Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity." in: Endocrinology, Vol. 150, Issue 12, pp. 5240-8, 2009 (PubMed).

Heart, Cline, Collis, Pongratz, Gray, Smith: "Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion." in: American journal of physiology. Endocrinology and metabolism, Vol. 296, Issue 6, pp. E1354-62, 2009 (PubMed).

Lacroix, Badonnel, Meunier, Tan, Schlegel-Le Poupon, Durieux, Monnerie, Baly, Congar, Salesse, Caillol: "Expression of insulin system in the olfactory epithelium: first approaches to its role and regulation." in: Journal of neuroendocrinology, Vol. 20, Issue 10, pp. 1176-90, 2008 (PubMed).

Yasuda, Yamamoto, Ochiai, Eguchi, Arishima: "Effects of growth factors on development of fetal islet B-cells in vitro." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, Vol. 69, Issue 8, pp. 807-11, 2007 (PubMed).

Duvillié, Heinis, Stetsyuk: "In vivo and in vitro techniques to study pancreas development and islet cell function." in: Endocrine development, Vol. 12, pp. 46-54, 2007 (PubMed).

Du, Lewis, Hanahan, Varmus: "Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion." in: PLoS biology, Vol. 5, Issue 10, pp. e276, 2007 (PubMed).

Ku, Lee: "The distribution and frequency of endocrine cells in the splenic lobe of grass lizard (Takydromus wolteri). An immunohistochemical study." in: European journal of histochemistry : EJH, Vol. 48, Issue 4, pp. 429-36, 2005 (PubMed).

Castaing, Guerci, Mallet, Czernichow, Ravassard, Scharfmann: "Efficient restricted gene expression in beta cells by lentivirus-mediated gene transfer into pancreatic stem/progenitor cells." in: Diabetologia, Vol. 48, Issue 4, pp. 709-19, 2005 (PubMed).

Yamamoto, Yasuda, Hori, Arishima, Eguchi: "Recovery in the fetal pancreatic islet following fetal administration of streptozotocin in the rat in vivo and in vitro." in: The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology, Vol. 281, Issue 2, pp. 1319-25, 2004 (PubMed).

Zhang, Davenport, Croyle, Haycraft, Yoder: "Disruption of IFT results in both exocrine and endocrine abnormalities in the pancreas of Tg737(orpk) mutant mice." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 85, Issue 1, pp. 45-64, 2004 (PubMed).

Ku, Lee, Lee: "Immunohistochemical study of the pancreatic endocrine cells in the BALB/c mice: an unique distributional pattern of glucagon." in: Journal of veterinary science, Vol. 3, Issue 3, pp. 167-73, 2003 (PubMed).

Duvillié, Attali, Aiello, Quemeneur, Scharfmann: "Label-retaining cells in the rat pancreas: location and differentiation potential in vitro." in: Diabetes, Vol. 52, Issue 8, pp. 2035-42, 2003 (PubMed).

Lewis, Klimstra, Varmus: "The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer." in: Genes & development, Vol. 17, Issue 24, pp. 3127-38, 2003 (PubMed).

Page, du Toit, Muller, Mattysen, Lyners: "An immunocytochemical profile of the endocrine pancreas using an occlusive duct ligation model." in: JOP : Journal of the pancreas, Vol. 1, Issue 4, pp. 191-203, 2002 (PubMed).

Elghazi, Cras-Méneur, Czernichow, Scharfmann: "Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 6, pp. 3884-9, 2002 (PubMed).

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