CACNA2D2 antibody (AA 20-200)

Catalog No. ABIN6214454

Product Details anti-CACNA2D2 Antibody

Target: CACNA2D2 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2))

Binding Specificity: AA 20-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA2D2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RPWPGCGPHP GPGTRRPTSG PPRPLWLLLP LLPLLAAPGA SAYSFPQQHT MQHWARRLEQ EVDGVMRIFG GVQQLREIYK DNRNLFEVQE NEPQKLVEKV AGDIESLLDR KVQALKRLAD AAENFQKAHR WQDNIKEEDI VYYDAKADAE LDDPESEDVE RGSKASTLRL DFIEDPNFKN K

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CACNA2D2 (NP_001167522.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CACNA2D2

Target: CACNA2D2 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 2 (CACNA2D2))

Alternative Name: CACNA2D2 (CACNA2D2 Products)

Synonyms: CACNA2D antibody, LUAC11.1 antibody, Cacna2d antibody, a2d2 antibody, du antibody, mKIAA0558 antibody, td antibody, torpid antibody, calcium voltage-gated channel auxiliary subunit alpha2delta 2 antibody, calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody, CACNA2D2 antibody, Cacna2d2 antibody

Background: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.,CACNA2D2,CACNA2D,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Neuroscience,Calcium Signaling,CACNA2D2

Molecular Weight: 122 kDa/129 kDa/130 kDa

Gene ID: 9254

UniProt: Q9NY47

Pathways: Skeletal Muscle Fiber Development