PPP2R2B antibody (AA 160-260)

Catalog No. ABIN6214771

Product Details anti-PPP2R2B Antibody

Target: PPP2R2B (Protein Phosphatase 2, Regulatory Subunit B, beta (PPP2R2B))

Binding Specificity: AA 160-260

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2R2B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KIRWLPQQNA AYFLLSTNDK TVKLWKVSER DKRPEGYNLK DEEGRLRDPA TITTLRVPVL RPMDLMVEAT PRRVFANAHT YHINSISVNS DYETYMSADD L

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 160-260 of human PP2A-B55beta/PR55beta/PP2A-B55beta/PR55beta/PPP2R2B (NP_858060.2).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PPP2R2B

Target: PPP2R2B (Protein Phosphatase 2, Regulatory Subunit B, beta (PPP2R2B))

Alternative Name: PPP2R2B (PPP2R2B Products)

Synonyms: B55BETA antibody, PP2AB55BETA antibody, PP2ABBETA antibody, PP2APR55B antibody, PP2APR55BETA antibody, PR2AB55BETA antibody, PR2ABBETA antibody, PR2APR55BETA antibody, PR52B antibody, PR55-BETA antibody, PR55BETA antibody, SCA12 antibody, Pppr2b2 antibody, 2900026H06Rik antibody, 6330404L05Rik antibody, E130009M08Rik antibody, PP2A-PR55B antibody, PP2A antibody, ppp2r2b-a antibody, ppp2r2c antibody, ppp2r2b antibody, zgc:101861 antibody, PPP2R2B antibody, protein phosphatase 2 regulatory subunit Bbeta antibody, protein phosphatase 2, regulatory subunit B, beta antibody, protein phosphatase 2 regulatory subunit B, beta L homeolog antibody, protein phosphatase 2 regulatory subunit B, beta antibody, protein phosphatase 2, regulatory subunit B, beta b antibody, PPP2R2B antibody, Ppp2r2b antibody, ppp2r2b.L antibody, ppp2r2b antibody, ppp2r2bb antibody

Background: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12.,PPP2R2B,B55BETA,PP2AB55BETA,PP2ABBETA,PP2APR55B,PP2APR55BETA,PR2AB55BETA,PR2ABBETA,PR2APR55BETA,PR52B,PR55-BETA,PR55BETA,SCA12,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centromere,Wnt/β-Catenin Signaling Pathway,Neuroscience,Neurodegenerative Diseases,PPP2R2B

Molecular Weight: 50 kDa/51 kDa/52 kDa/58 kDa/62 kDa

Gene ID: 5521

UniProt: Q00005

Pathways: PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Hepatitis C