PTPN13 antibody (AA 250-500)

Catalog No. ABIN6216830

Product Details anti-PTPN13 Antibody

Target: PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))

Binding Specificity: AA 250-500

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN13 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Sequence: QDENYFKDIL SDNSGREDSE NTFSPYQFKT SGPEKKPIPG IDVLSKKKIW ASSMDLLCTA DRDFSSGETA TYRRCHPEAV TVRTSTTPRK KEARYSDGSI ALDIFGPQKM DPIYHTRELP TSSAISSALD RIRERQKKLQ VLREAMNVEE PVRRYKTYHG DVFSTSSESP SIISSESDFR QVRRSEASKR FESSSGLPGV DETLSQGQSQ RPSRQYETPF EGNLINQEIM LKRQEEELMQ LQAKMALRQS R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human PTPN13 (NP_542416.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PTPN13

Target: PTPN13 (Protein tyrosine Phosphatase, Non-Receptor Type 13 (APO-1/CD95 (Fas)-Associated Phosphatase) (PTPN13))

Alternative Name: PTPN13 (PTPN13 Products)

Synonyms: FAP-1 antibody, PNP1 antibody, PTP-BAS antibody, PTP-BL antibody, PTP1E antibody, PTPL1 antibody, PTPLE antibody, hPTP1E antibody, PTPN13 antibody, AI324989 antibody, Ptpri antibody, RIP antibody, Ptp-bl antibody, ptp antibody, wu:fb50g04 antibody, zgc:162319 antibody, protein tyrosine phosphatase, non-receptor type 13 antibody, tyrosine-protein phosphatase non-receptor type 13 antibody, PTPN13 antibody, LOC100540743 antibody, ptpn13 antibody, Ptpn13 antibody

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.,PTPN13,FAP-1,PNP1,PTP-BAS,PTP-BL,PTP1E,PTPL1,PTPLE,hPTP1E,Cancer,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,PTPN13

Molecular Weight: 255 kDa/274 kDa/276 kDa/277 kDa

Gene ID: 5783

UniProt: Q12923