CYP24A1 antibody (AA 36-448)

Catalog No. ABIN6218917

Product Details anti-CYP24A1 Antibody

Target: CYP24A1 (Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 (CYP24A1))

Binding Specificity: AA 36-448

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP24A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PQPREVPVCP LTAGGETQNA AALPGPTSWP LLGSLLQILW KGGLKKQHDT LVEYHKKYGK IFRMKLGSFE SVHLGSPCLL EALYRTESAY PQRLEIKPWK AYRDYRKEGY GLLILEGEDW QRVRSAFQKK LMKPGEVMKL DNKINEVLAD FMGRIDELCD ERGHVEDLYS ELNKWSFESI CLVLYEKRFG LLQKNAGDEA VNFIMAIKTM MSTFGRMMVT PVELHKSLNT KVWQDHTLAW DTIFKSVKAC IDNRLEKYSQ QPSADFLCDI YHQNRLSKKE LYAAVTELQL AAVETTANSL MWILYNLSRN PQVQQKLLKE IQSVLPENQV PRAEDLRNMP YLKACLKESM RLTPSVPFTT RTLDKATVLG EYALPKGIVR KYDIQATDNE PVEMLHSGTL VPSRELPIAF CQR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 36-448 of human CYP24A1 (NP_001122387.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CYP24A1

Target: CYP24A1 (Cytochrome P450, Family 24, Subfamily A, Polypeptide 1 (CYP24A1))

Alternative Name: CYP24A1 (CYP24A1 Products)

Synonyms: CP24 antibody, CYP24 antibody, HCAI antibody, P450-CC24 antibody, 24-OHase antibody, Cyp24 antibody, 25-hydroxyvitaminD324-hydroxylase antibody, VITD12 antibody, CP450CC24 antibody, cytochrome P450 family 24 subfamily A member 1 antibody, cytochrome P450, family 24, subfamily a, polypeptide 1 antibody, cytochrome P450, family 24, subfamily A, polypeptide 1 antibody, CYP24A1 antibody, Cyp24a1 antibody

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,CYP24A1,CP24,CYP24,HCAI,HCINF1,P450-CC24,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Cytochromes,Mitochondrial markers,Lipid Metabolism,Cytochromes,Lipases,Cardiovascular,Lipids,CYP24A1

Molecular Weight: 43 kDa/51 kDa/58 kDa

Gene ID: 1591

UniProt: Q07973

Pathways: Metabolism of Steroid Hormones and Vitamin D