PNP antibody (AA 1-289)

Catalog No. ABIN6221461

Product Details anti-PNP Antibody

Target: PNP (NP) (Nucleoside Phosphorylase (NP))

Binding Specificity: AA 1-289

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Sequence: MENGYTYEDY KNTAEWLLSH TKHRPQVAII CGSGLGGLTD KLTQAQIFDY GEIPNFPRST VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP NDERFGDRFP AMSDAYDRTM RQRALSTWKQ MGEQRELQEG TYVMVAGPSF ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE SLEKANHEEV LAAGKQAAQK LEQFVSILMA SIPLPDKAS

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-289 of human PNP (NP_000261.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IP,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PNP

Target: PNP (NP) (Nucleoside Phosphorylase (NP))

Alternative Name: PNP (NP Products)

Synonyms: NP antibody, PRO1837 antibody, PUNP antibody, Np antibody, AL024301 antibody, AU015798 antibody, Np-1 antibody, Np-2 antibody, Pnp1 antibody, purine nucleoside phosphorylase antibody, purine-nucleoside phosphorylase antibody, PNP antibody, Pnp antibody

Target Type: Viral Protein

Background: This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.,PNP,NP,PRO1837,PUNP,Neuroscience,Neurodegenerative Diseases,PNP

Molecular Weight: 32 kDa

Gene ID: 4860

UniProt: P00491

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus