ZCCHC11 antibody (C-Term)

Catalog No. ABIN6242704

This anti-ZCCHC11 antibody is a Rabbit Polyclonal antibody detecting ZCCHC11 in WB. Suitable for Mouse.

Quick Overview for ZCCHC11 antibody (C-Term) (ABIN6242704)

Target: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZCCHC11 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB51164

Product Details anti-ZCCHC11 Antibody

Binding Specificity: AA 1568-1600, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This (Mouse) Zcchc11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1568-1600 amino acids from the C-terminal region of (Mouse) Zcchc11.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for ZCCHC11

Target: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Alternative Name: Zcchc11

Background: Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B (By similarity). Also catalyzes the 3' uridylation of miR- 26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation (By similarity).

Molecular Weight: 184650

UniProt: B2RX14

Pathways: Stem Cell Maintenance