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DOT1L antibody (C-Term)

DOT1L Reactivity: Human IHC (p) Host: Rabbit Polyclonal RB2773 unconjugated
Catalog No. ABIN6243177
  • Target See all DOT1L Antibodies
    DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))
    Binding Specificity
    • 15
    • 9
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1390-1420, C-Term
    Reactivity
    • 50
    • 17
    • 17
    • 15
    Human
    Host
    • 39
    • 11
    Rabbit
    Clonality
    • 37
    • 13
    Polyclonal
    Conjugate
    • 27
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DOT1L antibody is un-conjugated
    Application
    • 35
    • 20
    • 14
    • 13
    • 13
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This KMT4 / Dot1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1390~1420 amino acids from the C-terminal region of human DOT1L.
    Clone
    RB2773
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DOT1L Primary Antibody
  • Application Notes
    IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Nguyen, Xiao, Neppl, Kallin, Li, Chen, Wang, Xiao, Zhang: "DOT1L regulates dystrophin expression and is critical for cardiac function." in: Genes & development, Vol. 25, Issue 3, pp. 263-74, (2011) (PubMed).

    Comty, Wathen, Shapiro: "Uremic pericarditis." in: Cardiovascular clinics, Vol. 7, Issue 3, pp. 219-35, (1977) (PubMed).

  • Target
    DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))
    Alternative Name
    KMT4 / Dot1L (DOT1L Products)
    Synonyms
    NV11307 antibody, DOT1L antibody, DOT1 antibody, KMT4 antibody, A630076O07 antibody, AW907654 antibody, Dot1 antibody, mDot1 antibody, histone-lysine N-methyltransferase, H3 lysine-79 specific antibody, DOT1 like histone lysine methyltransferase antibody, histone methyltransferase antibody, DOT1-like, histone H3 methyltransferase (S. cerevisiae) antibody, LOC100116648 antibody, DOT1L antibody, DOT1 antibody, Dot1l antibody
    Background
    Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
    Molecular Weight
    164856
    NCBI Accession
    NP_115871
    UniProt
    Q8TEK3
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