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JAK1 antibody (pTyr1022, pTyr1023)

JAK1 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6255762
  • Target See all JAK1 Antibodies
    JAK1 (Janus Kinase 1 (JAK1))
    Binding Specificity
    • 16
    • 16
    • 11
    • 10
    • 10
    • 7
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1022, pTyr1023
    Reactivity
    • 107
    • 81
    • 61
    • 2
    • 2
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 87
    • 26
    • 1
    • 1
    Rabbit
    Clonality
    • 81
    • 34
    Polyclonal
    Conjugate
    • 51
    • 8
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This JAK1 antibody is un-conjugated
    Application
    • 74
    • 37
    • 25
    • 21
    • 17
    • 14
    • 11
    • 10
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    Phospho-JAK1 (Tyr1022/Tyr1023) Antibody detects endogenous levels of JAK1 only when phosphorylated at Tyr1034/Tyr1035, which site historically referenced as Tyr1022/Tyr1023.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human JAK1 around the phosphorylation site of Tyr1022/Tyr1023.
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:500, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Fukasawa, Yoshizaki, Ebata, Yoshizaki-Ogawa, Asano, Enomoto, Miyagawa, Kazoe, Mawatari, Kitamori, Sato: "Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model." in: eLife, Vol. 10, (2021) (PubMed).

    Chen, Zhou, Liu, Huang, Liu, Kang, Chen, Guo, Zhu, Sun: "Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway." in: Oncology reports, Vol. 39, Issue 3, pp. 1081-1089, (2018) (PubMed).

    Tu, Yu, Zhang, Shi, Xu, Hu, Gan, He, Dong, Han, Huang, Pan, Zhang: "A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway." in: Biochemical pharmacology, Vol. 155, pp. 275-287, (2018) (PubMed).

    Bai, Wang, Han, Xie, Ji, Yin, Chen, Wang, Jiang, Qi, Jiang: "BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo." in: Molecular carcinogenesis, Vol. 56, Issue 3, pp. 1137-1149, (2017) (PubMed).

  • Target
    JAK1 (Janus Kinase 1 (JAK1))
    Alternative Name
    JAK1 (JAK1 Products)
    Synonyms
    JAK1A antibody, JAK1B antibody, JTK3 antibody, AA960307 antibody, C130039L05Rik antibody, wu:fb93e10 antibody, jak1 antibody, Janus kinase 1 antibody, tyrosine-protein kinase JAK1 antibody, JAK1 antibody, Jak1 antibody, jak1 antibody, LOC100286690 antibody
    Background

    Description: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).

    Gene: JAK1

    Molecular Weight
    130kDa
    Gene ID
    3716
    UniProt
    P23458
    Pathways
    JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response
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