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ErbB2/Her2 antibody (pTyr877)

ErbB2/Her2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, IP, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6256054
  • Target See all ErbB2/Her2 Antibodies
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Binding Specificity
    • 32
    • 29
    • 27
    • 26
    • 25
    • 23
    • 22
    • 21
    • 18
    • 16
    • 15
    • 13
    • 10
    • 10
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    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
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    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    pTyr877
    Reactivity
    • 509
    • 186
    • 163
    • 34
    • 10
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 408
    • 148
    • 11
    • 5
    • 3
    • 3
    Rabbit
    Clonality
    • 411
    • 164
    • 2
    Polyclonal
    Conjugate
    • 266
    • 46
    • 37
    • 29
    • 25
    • 23
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 8
    • 8
    • 8
    • 8
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This ErbB2/Her2 antibody is un-conjugated
    Application
    • 296
    • 228
    • 139
    • 98
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    • 90
    • 80
    • 66
    • 49
    • 28
    • 19
    • 12
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificity
    Phospho-HER2/ErbB2 (Tyr877) Antibody detects endogenous levels of HER2/ErbB2 only when phosphorylated at Tyrosine 877.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogen
    A synthesized peptide derived from human HER2/ErbB2 around the phosphorylation site of Tyr877.
    Isotype
    IgG
    Top Product
    Discover our top product ErbB2/Her2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IP 1:100-1:500, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Alternative Name
    ERBB2 (ErbB2/Her2 Products)
    Synonyms
    CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, Erbb-2 antibody, Neu antibody, c-erbB2 antibody, c-neu antibody, mKIAA3023 antibody, wu:fv70f10 antibody, zgc:63601 antibody, erb2 antibody, erb-b2 receptor tyrosine kinase 2 antibody, ERBB2 antibody, Erbb2 antibody, erbb2 antibody
    Background

    Description: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

    Gene: ERBB2

    Molecular Weight
    185kDa
    Gene ID
    2064
    UniProt
    P04626
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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