5HT1B Receptor antibody (Internal Region)

Catalog No. ABIN6256876

Product Details anti-5HT1B Receptor Antibody

Target: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This 5HT1B Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: 5HT1B Receptor Antibody detects endogenous levels of total 5HT1B Receptor.

Predicted Reactivity: Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human 5HT1B Receptor, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for 5HT1B Receptor

Target: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Alternative Name: HTR1B (HTR1B Products)

Synonyms: 5-HT1B antibody, 5-HT1DB antibody, HTR1D2 antibody, HTR1DB antibody, S12 antibody, 5-HT1Db antibody, 5-HT1-LIKE antibody, HTR1B antibody, 5-HT-dro2B antibody, 5-HT1BDro antibody, 5-HT[1B]Dro antibody, 5-HT[[1BDro]] antibody, 5-HT[[1B]] antibody, 5-HT[[1B]]DRO antibody, 5-HT[[1B]]Dro antibody, 5-HT[[dro2B]] antibody, 5HT-R2B antibody, 5HT-dro2B antibody, 5HT-dro[[2B]] antibody, 5HT1B antibody, 5htdro2b antibody, CG15113 antibody, CG30126 antibody, DRO2B antibody, Dm5HTdro2B antibody, Dmel\\CG15113 antibody, Dmel_CG30126 antibody, d5-HT1B antibody, 5-HT-1B antibody, zgc:194666 antibody, zgc:194690 antibody, 5-hydroxytryptamine receptor 1B antibody, 5-hydroxytryptamine (serotonin) receptor 1B antibody, HTR1B antibody, Htr1b antibody, 5-HT1B antibody, htr1b antibody

Background:

Description: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Gene: HTR1B

Molecular Weight: 48 kDa

Gene ID: 3351

UniProt: P28222

Pathways: JAK-STAT Signaling, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, S100 Proteins