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SH2B2 antibody (N-Term)

SH2B2 Reactivity: Human, Rat, Mouse ELISA, WB, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6256908
  • Target See all SH2B2 Antibodies
    SH2B2 (SH2B Adaptor Protein 2 (SH2B2))
    Binding Specificity
    N-Term
    Reactivity
    Human, Rat, Mouse
    Host
    • 11
    Rabbit
    Clonality
    • 11
    Polyclonal
    Conjugate
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SH2B2 antibody is un-conjugated
    Application
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    SH2B2 Antibody detects endogenous levels of total SH2B2.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SH2B2, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SH2B2 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    SH2B2 (SH2B Adaptor Protein 2 (SH2B2))
    Alternative Name
    SH2B2 (SH2B2 Products)
    Synonyms
    APS antibody, Aps antibody, SH2B adaptor protein 2 antibody, SH2B2 antibody, Sh2b2 antibody
    Background

    Description: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.

    Gene: SH2B2

    Molecular Weight
    67 kDa
    Gene ID
    10603
    UniProt
    O14492
    Pathways
    Carbohydrate Homeostasis, Brown Fat Cell Differentiation
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