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GPR161 antibody (Internal Region)

GPR161 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6257220
  • Target See all GPR161 Antibodies
    GPR161 (G Protein-Coupled Receptor 161 (GPR161))
    Binding Specificity
    • 15
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 38
    • 10
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 1
    • 1
    Human
    Host
    • 36
    • 2
    Rabbit
    Clonality
    • 36
    • 2
    Polyclonal
    Conjugate
    • 19
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GPR161 antibody is un-conjugated
    Application
    • 31
    • 13
    • 13
    • 12
    • 12
    • 9
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificity
    GPR161 Antibody detects endogenous levels of total GPR161.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human GPR161, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product GPR161 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    GPR161 (G Protein-Coupled Receptor 161 (GPR161))
    Alternative Name
    GPR161 (GPR161 Products)
    Synonyms
    RE2 antibody, Gm208 antibody, Gm208Gpr antibody, vl antibody, RGD1563245 antibody, si:bz20i5.4 antibody, si:rp71-20i5.4 antibody, G protein-coupled receptor 161 antibody, GPR161 antibody, Gpr161 antibody, gpr161 antibody
    Background

    Description: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

    Gene: GPR161

    Molecular Weight
    65 kDa
    Gene ID
    23432
    UniProt
    Q8N6U8
    Pathways
    cAMP Metabolic Process
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