GPR161 antibody (Internal Region)
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- Target See all GPR161 Antibodies
- GPR161 (G Protein-Coupled Receptor 161 (GPR161))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GPR161 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- GPR161 Antibody detects endogenous levels of total GPR161.
- Predicted Reactivity
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human GPR161, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product GPR161 Primary Antibody
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- GPR161 (G Protein-Coupled Receptor 161 (GPR161))
- Alternative Name
- GPR161 (GPR161 Products)
- Synonyms
- RE2 antibody, Gm208 antibody, Gm208Gpr antibody, vl antibody, RGD1563245 antibody, si:bz20i5.4 antibody, si:rp71-20i5.4 antibody, G protein-coupled receptor 161 antibody, GPR161 antibody, Gpr161 antibody, gpr161 antibody
- Background
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Description: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Gene: GPR161
- Molecular Weight
- 65 kDa
- Gene ID
- 23432
- UniProt
- Q8N6U8
- Pathways
- cAMP Metabolic Process
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