ELL2 antibody (Internal Region)

Catalog No. ABIN6257461

Product Details anti-ELL2 Antibody

Target: ELL2 (Elongation Factor, RNA Polymerase II, 2 (ELL2))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: ELL2 Antibody detects endogenous levels of total ELL2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ELL2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for ELL2

Target: ELL2 (Elongation Factor, RNA Polymerase II, 2 (ELL2))

Alternative Name: ELL2 (ELL2 Products)

Synonyms: cb244 antibody, fb78f03 antibody, sb:cb244 antibody, im:3814960 antibody, wu:fb78f03 antibody, xell2 antibody, MGC82755 antibody, ELL2 antibody, elongation factor for RNA polymerase II 2 antibody, elongation factor, RNA polymerase II, 2 antibody, elongation factor, RNA polymerase II 2 S homeolog antibody, elongation factor, RNA polymerase II 2 antibody, elongation factor RNA polymerase II 2 antibody, ELL2 antibody, ell2 antibody, ell2.S antibody, Ell2 antibody

Background:

Description: Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.

Gene: ELL2

Molecular Weight: 72 kDa

Gene ID: 22936

UniProt: O00472