SRY antibody (Internal Region)

Catalog No. ABIN6257506

Product Details anti-SRY Antibody

Target: SRY (Sex Determining Region Y (SRY))

Binding Specificity: Internal Region

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRY antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: SRY Antibody detects endogenous levels of total SRY.

Predicted Reactivity: Pig,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SRY, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SRY

Target: SRY (Sex Determining Region Y (SRY))

Alternative Name: SRY (SRY Products)

Synonyms: SRXX1 antibody, SRXY1 antibody, TDF antibody, TDY antibody, SRYGENE antibody, Sry1 antibody, Sry3BI antibody, Tdf antibody, Tdy antibody, SRY antibody, sex determining region Y antibody, sex determining region of Chr Y antibody, SRY antibody, Sry antibody

Background:

Description: Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.

Gene: SRY

Molecular Weight: 37 kDa

Gene ID: 6736

UniProt: Q05066