PHACTR4 antibody (Internal Region)

Catalog No. ABIN6257850

Product Details anti-PHACTR4 Antibody

Target: PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))

Binding Specificity: Internal Region

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHACTR4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: PHACTR4 Antibody detects endogenous levels of total PHACTR4.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PHACTR4, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for PHACTR4

Target: PHACTR4 (Phosphatase and Actin Regulator 4 (PHACTR4))

Alternative Name: PHACTR4 (PHACTR4 Products)

Synonyms: 3110001B12Rik antibody, AI527228 antibody, AW495572 antibody, C330013F19Rik antibody, N28169 antibody, mKIAA4120 antibody, phactr4 antibody, zgc:63484 antibody, zgc:123224 antibody, phosphatase and actin regulator 4 antibody, phosphatase and actin regulator 4b antibody, phosphatase and actin regulator 4 L homeolog antibody, phosphatase and actin regulator 4 S homeolog antibody, phosphatase and actin regulator 4a antibody, Phactr4 antibody, phactr4b antibody, PHACTR4 antibody, phactr4.L antibody, phactr4.S antibody, Tsp_08786 antibody, phactr4 antibody, phactr4a antibody

Background:

Description: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).

Gene: PHACTR4

Molecular Weight: 80 kDa

Gene ID: 65979

UniProt: Q8IZ21

Pathways: Tube Formation