MAS1 antibody (Internal Region)

Catalog No. ABIN6257884

Product Details anti-MAS1 Antibody

Target: MAS1 (MAS1 Oncogene (MAS1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: MAS Antibody detects endogenous levels of total MAS.

Predicted Reactivity: Bovine,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MAS, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for MAS1

Target: MAS1 (MAS1 Oncogene (MAS1))

Alternative Name: MAS1 (MAS1 Products)

Synonyms: MAS antibody, Mas-1 antibody, c-mas antibody, MAS1 antibody, MAS1 proto-oncogene, G protein-coupled receptor antibody, MAS1 oncogene antibody, proto-oncogene Mas antibody, MAS1 antibody, Mas1 antibody, LOC703105 antibody

Background:

Description: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Gene: MAS1

Molecular Weight: 37 kDa

Gene ID: 4142

UniProt: P04201

Pathways: ACE Inhibitor Pathway, Regulation of Carbohydrate Metabolic Process