SCN4A antibody (Internal Region)

Catalog No. ABIN6258330

Product Details anti-SCN4A Antibody

Target: SCN4A (Sodium Channel, Voltage-Gated, Type IV, alpha Subunit (SCN4A))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN4A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: SCN4A Antibody detects endogenous levels of total SCN4A.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SCN4A, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SCN4A

Target: SCN4A (Sodium Channel, Voltage-Gated, Type IV, alpha Subunit (SCN4A))

Alternative Name: SCN4A (SCN4A Products)

Synonyms: Nav1.4 antibody, SkM1 antibody, mH2 antibody, HOKPP2 antibody, HYKPP antibody, HYPP antibody, NAC1A antibody, Na(V)1.4 antibody, NCHVS antibody, microI antibody, Nav1.4b antibody, sodium channel, voltage-gated, type IV, alpha antibody, sodium voltage-gated channel alpha subunit 4 antibody, sodium channel, voltage-gated, type IV, alpha, b antibody, Scn4a antibody, SCN4A antibody, scn4ab antibody

Background:

Description: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.

Gene: SCN4A

Molecular Weight: 208 kDa

Gene ID: 6329

UniProt: P35499