TCHP antibody (C-Term)

Catalog No. ABIN6258431

Product Details anti-TCHP Antibody

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCHP antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: TCHP Antibody detects endogenous levels of total TCHP.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TCHP, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for TCHP

Target: TCHP (Trichoplein, Keratin Filament Binding (TCHP))

Alternative Name: TCHP (TCHP Products)

Synonyms: TpMs antibody, A930031F18Rik antibody, AV279199 antibody, RGD1310813 antibody, zgc:136634 antibody, trichoplein keratin filament binding antibody, trichoplein, keratin filament binding antibody, trichoplein, keratin filament binding L homeolog antibody, TCHP antibody, tchp antibody, Tchp antibody, tchp.L antibody

Background:

Description: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701). Is a negative regulator of ciliogenesis (PubMed:25270598).

Gene: TCHP

Molecular Weight: ?65 kDa

Gene ID: 84260

UniProt: Q9BT92