VPS4B antibody (Internal Region)
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- Target See all VPS4B (vps4b) Antibodies
- VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This VPS4B antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- VPS4B Antibody detects endogenous levels of total VPS4B.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human VPS4B, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product vps4b Primary Antibody
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- Application Notes
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))
- Alternative Name
- VPS4B (vps4b Products)
- Synonyms
- zgc:63682 antibody, vps4a antibody, SKD1 antibody, SKD1B antibody, VPS4-2 antibody, 8030489C12Rik antibody, Skd1 antibody, vacuolar protein sorting 4 homolog B antibody, vacuolar protein sorting 4 homolog B S homeolog antibody, vacuolar protein sorting 4b homolog B (S. cerevisiae) antibody, vacuolar protein sorting 4 homolog B (S. cerevisiae) antibody, vacuolar protein sorting 4B antibody, Vps4b antibody, vps4b.S antibody, vps4b antibody, VPS4B antibody
- Background
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Description: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Gene: VPS4B
- Molecular Weight
- 49 kDa
- Gene ID
- 9525
- UniProt
- O75351
- Pathways
- Microtubule Dynamics, CXCR4-mediated Signaling Events
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