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CELF1 antibody (N-Term)

CELF1 Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6258447
  • Target See all CELF1 Antibodies
    CELF1 (CUGBP, Elav-Like Family Member 1 (CELF1))
    Binding Specificity
    • 14
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 51
    • 22
    • 21
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 39
    • 12
    Rabbit
    Clonality
    • 39
    • 12
    Polyclonal
    Conjugate
    • 27
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CELF1 antibody is un-conjugated
    Application
    • 35
    • 24
    • 19
    • 8
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    CELF-1 Antibody detects endogenous levels of total CELF-1.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CELF-1, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CELF1 Primary Antibody
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    CELF1 (CUGBP, Elav-Like Family Member 1 (CELF1))
    Alternative Name
    CELF1 (CELF1 Products)
    Synonyms
    CUGBP1 antibody, BRUNOL2 antibody, CUG-BP antibody, CUGBP antibody, EDEN-BP antibody, NAB50 antibody, NAPOR antibody, hNab50 antibody, 1600010O03Rik antibody, AA407467 antibody, Brunol2 antibody, CUG-BP1 antibody, Cugbp1 antibody, D2Wsu101e antibody, HNAB50 antibody, Bruno-like antibody, brul antibody, cb920 antibody, cugbp1 antibody, brunol2 antibody, cug-bp antibody, cug-bp1 antibody, cugbp antibody, cugbp1-a antibody, eden-bp antibody, edenbp antibody, nab50 antibody, CUGBP Elav-like family member 1 antibody, CUGBP, Elav-like family member 1 antibody, cugbp, Elav-like family member 1 antibody, CUGBP Elav-like family member 1 L homeolog antibody, CELF1 antibody, Celf1 antibody, celf1 antibody, celf1.L antibody
    Background

    Description: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233).

    Gene: CELF1

    Molecular Weight
    52 kDa
    Gene ID
    10658
    UniProt
    Q92879
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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