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Usp30 antibody (N-Term)

Usp30 Reactivity: Human, Mouse, Rat WB, ELISA, IF, IHC, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6258562
  • Target See all Usp30 Antibodies
    Usp30 (Ubiquitin Specific Peptidase 30 (Usp30))
    Binding Specificity
    • 10
    • 8
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 34
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 33
    • 1
    Rabbit
    Clonality
    • 33
    • 1
    Polyclonal
    Conjugate
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Usp30 antibody is un-conjugated
    Application
    • 23
    • 17
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Specificity
    USP30 Antibody detects endogenous levels of total USP30.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human USP30, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    Usp30 (Ubiquitin Specific Peptidase 30 (Usp30))
    Alternative Name
    USP30 (Usp30 Products)
    Synonyms
    6330590F17Rik antibody, AI851327 antibody, D5Ertd483e antibody, si:dkey-72n1.2 antibody, ubiquitin specific peptidase 30 antibody, ubiquitin specific peptidase 30 L homeolog antibody, USP30 antibody, usp30 antibody, usp30.L antibody, Usp30 antibody
    Background

    Description: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).

    Gene: USP30

    Molecular Weight
    60 kDa
    Gene ID
    84749
    UniProt
    Q70CQ3
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