CDK5R1 antibody (N-Term)

Catalog No. ABIN6258750

Product Details anti-CDK5R1 Antibody

Target: CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK5R1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: CDK5R1/P35 Antibody detects endogenous levels of total CDK5R1/P35.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CDK5R1/P35, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CDK5R1

Target: CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))

Alternative Name: CDK5R1 (CDK5R1 Products)

Synonyms: CDK5P35 antibody, CDK5R antibody, NCK5A antibody, p23 antibody, p25 antibody, p35 antibody, p35nck5a antibody, cdk5r1 antibody, zgc:92814 antibody, CDK5R1 antibody, Cdk5r antibody, P25/P35 antibody, D11Bwg0379e antibody, Xp35.1 antibody, cyclin dependent kinase 5 regulatory subunit 1 antibody, cyclin-dependent kinase 5, regulatory subunit 1b (p35) antibody, cyclin-dependent kinase 5 regulatory subunit 1 antibody, S100 calcium binding protein A9 antibody, cyclin-dependent kinase 5, regulatory subunit 1 (p35) antibody, cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog antibody, CDK5R1 antibody, cdk5r1b antibody, Cdk5r1 antibody, S100A9 antibody, cdk5r1.L antibody

Target Type: Viral Protein

Background:

Description: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Gene: CDK5R1

Molecular Weight: 38 kDa

Gene ID: 8851

UniProt: Q15078

Pathways: Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity