KCNQ5 antibody (C-Term)

Catalog No. ABIN6258866

Product Details anti-KCNQ5 Antibody

Target: KCNQ5 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 5 (KCNQ5))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNQ5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: KCNQ5 Antibody detects endogenous levels of total KCNQ5.

Predicted Reactivity: Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KCNQ5, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for KCNQ5

Target: KCNQ5 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 5 (KCNQ5))

Alternative Name: KCNQ5 (KCNQ5 Products)

Synonyms: KCNQ5 antibody, si:dkey-29l6.1 antibody, Kcnq5l antibody, Kv7.5 antibody, 7730402H11 antibody, 9230107O05Rik antibody, AA589396 antibody, D1Mgi1 antibody, potassium voltage-gated channel subfamily Q member 5 antibody, potassium voltage-gated channel, KQT-like subfamily, member 5a antibody, potassium voltage-gated channel, KQT-like subfamily, member 5 antibody, potassium voltage-gated channel, subfamily Q, member 5 antibody, KCNQ5 antibody, kcnq5a antibody, Kcnq5 antibody

Background:

Description: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.

Gene: KCNQ5

Molecular Weight: 100 kDa

Gene ID: 56479

UniProt: Q9NR82