KCNE2 antibody (Internal Region)

Catalog No. ABIN6258938

Product Details anti-KCNE2 Antibody

Target: KCNE2 (Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 (KCNE2))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNE2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: KCNE2 Antibody detects endogenous levels of total KCNE2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human KCNE2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for KCNE2

Target: KCNE2 (Potassium Voltage-Gated Channel, Isk-Related Family, Member 2 (KCNE2))

Alternative Name: KCNE2 (KCNE2 Products)

Synonyms: ATFB4 antibody, LQT5 antibody, LQT6 antibody, MIRP1 antibody, Mirp1 antibody, MiRP1 antibody, 2200002I16Rik antibody, AW048273 antibody, potassium voltage-gated channel subfamily E regulatory subunit 2 antibody, potassium voltage-gated channel, Isk-related subfamily, gene 2 antibody, KCNE2 antibody, Kcne2 antibody

Background:

Description: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505).

Gene: KCNE2

Molecular Weight: ?14 kDa

Gene ID: 9992

UniProt: Q9Y6J6