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NFE2L1 antibody (N-Term)

NFE2L1 Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259245
  • Target See all NFE2L1 Antibodies
    NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
    Binding Specificity
    • 12
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 42
    • 18
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 37
    • 5
    Rabbit
    Clonality
    • 38
    • 4
    Polyclonal
    Conjugate
    • 22
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NFE2L1 antibody is un-conjugated
    Application
    • 30
    • 20
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificity
    NFE2L1 Antibody detects endogenous levels of total NFE2L1.
    Predicted Reactivity
    Pig,Bovine,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human NFE2L1, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product NFE2L1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
    Alternative Name
    NFE2L1 (NFE2L1 Products)
    Synonyms
    LCR-F1 antibody, NRF1 antibody, TCF11 antibody, AA408798 antibody, AW212678 antibody, Lcrf1 antibody, TCF-11 antibody, nfe2l1 antibody, nuclear factor, erythroid 2 like 1 antibody, nuclear factor, erythroid derived 2,-like 1 antibody, nuclear factor, erythroid 2-like 1 antibody, nuclear factor, erythroid 2 like 1 S homeolog antibody, nuclear factor, erythroid 2-like 1a antibody, NFE2L1 antibody, Nfe2l1 antibody, nfe2l1.S antibody, nfe2l1a antibody
    Background

    Description: Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482).

    Gene: NFE2L1

    Molecular Weight
    82 kDa
    Gene ID
    4779
    UniProt
    Q14494
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