SLC24A6 antibody (C-Term)

Catalog No. ABIN6259261

Product Details anti-SLC24A6 Antibody

Target: SLC24A6 (Solute Carrier Family 24 (Sodium/potassium/calcium Exchanger), Member 6 (SLC24A6))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC24A6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: SLC24A6 Antibody detects endogenous levels of total SLC24A6.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SLC24A6, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SLC24A6

Target: SLC24A6 (Solute Carrier Family 24 (Sodium/potassium/calcium Exchanger), Member 6 (SLC24A6))

Alternative Name: SLC8B1 (SLC24A6 Products)

Synonyms: slc24a6 antibody, NCKX6 antibody, NCLX antibody, SLC24A6 antibody, AF261233 antibody, Slc24a6 antibody, solute carrier family 8 member B1 antibody, solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 antibody, solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 S homeolog antibody, SLC8B1 antibody, slc8b1 antibody, Slc8b1 antibody, slc8b1.S antibody

Background:

Description: Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069).

Gene: SLC8B1

Molecular Weight: 60 kDa

Gene ID: 80024

UniProt: Q6J4K2

Pathways: Carbohydrate Homeostasis