FIL1d antibody (Internal Region)

Catalog No. ABIN6259266

Product Details anti-FIL1d Antibody

Target: FIL1d (Interleukin 1 delta (FIL1d))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FIL1d antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: IL1F5 Antibody detects endogenous levels of total IL1F5.

Predicted Reactivity: Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IL1F5, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for FIL1d

Target: FIL1d (Interleukin 1 delta (FIL1d))

Alternative Name: IL36RN (FIL1d Products)

Synonyms: AI413231 antibody, Fil1delta antibody, IL36RN antibody, Il-1h3 antibody, Il1hy1 antibody, FIL1 antibody, FIL1(DELTA) antibody, FIL1D antibody, IL1F5 antibody, IL1HY1 antibody, IL1L1 antibody, IL1RP3 antibody, IL36RA antibody, PSORP antibody, Il1f5 antibody, interleukin 1 family, member 5 (delta) antibody, interleukin 36 receptor antagonist antibody, Il1f5 antibody, IL36RN antibody, Il36rn antibody

Background:

Description: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.

Gene: IL36RN

Molecular Weight: 17 kDa

Gene ID: 26525

UniProt: Q9UBH0