Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

MUL1 antibody (Internal Region)

MUL1 Reactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259500
  • Target See all MUL1 Antibodies
    MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
    Binding Specificity
    • 18
    • 9
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 47
    • 24
    • 21
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 45
    • 2
    Rabbit
    Clonality
    • 46
    • 1
    Polyclonal
    Conjugate
    • 20
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MUL1 antibody is un-conjugated
    Application
    • 45
    • 16
    • 15
    • 14
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    MUL1 Antibody detects endogenous levels of total MUL1.
    Predicted Reactivity
    Pig,Bovine,Horse,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MUL1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MUL1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))
    Alternative Name
    MUL1 (MUL1 Products)
    Synonyms
    C1orf166 antibody, GIDE antibody, MAPL antibody, MULAN antibody, RNF218 antibody, RP11-401M16.2 antibody, mul1 antibody, zgc:92166 antibody, 0610009K11Rik antibody, AV000801 antibody, Gide antibody, RGD1309944 antibody, im:7146383 antibody, zgc:165594 antibody, mitochondrial E3 ubiquitin protein ligase 1 antibody, mitochondrial E3 ubiquitin protein ligase 1 L homeolog antibody, mitochondrial E3 ubiquitin protein ligase 1a antibody, mitochondrial ubiquitin ligase activator of NFKB 1 antibody, mitochondrial E3 ubiquitin protein ligase 1b antibody, MUL1 antibody, mul1.L antibody, mul1a antibody, Mul1 antibody, mul1b antibody
    Background

    Description: Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in the control of mitochondrial morphology by promoting mitchondrial fragmentation, and influences mitochondrial localization (PubMed:19407830, PubMed:18207745, PubMed:18213395). Likely to promote mitchondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway (PubMed:24898855). May also be involved in the sumoylation of the membrane fission protein DNM1L (PubMed:18207745, PubMed:19407830). Inhibits cell growth (PubMed:18591963, PubMed:22410793). When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis (PubMed:23399697). Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response (PubMed:23399697). Can mediate DDX58 sumoylation and disrupt its polyubiquitination (PubMed:23399697).

    Gene: MUL1

    Molecular Weight
    38 kDa
    Gene ID
    79594
    UniProt
    Q969V5
    Pathways
    Positive Regulation of Endopeptidase Activity
You are here:
Support