CHML antibody (Internal Region)

Catalog No. ABIN6259562

Product Details anti-CHML Antibody

Target: CHML (Choroideremia-Like (Rab Escort Protein 2) (CHML))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHML antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: CHML Antibody detects endogenous levels of total CHML.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CHML, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CHML

Target: CHML (Choroideremia-Like (Rab Escort Protein 2) (CHML))

Alternative Name: CHML (CHML Products)

Synonyms: AI450814 antibody, E030003F13Rik antibody, REP-2 antibody, Rep2 antibody, REP2 antibody, choroideremia-like antibody, CHM like, Rab escort protein 2 antibody, Chml antibody, CHML antibody

Background:

Description: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.

Gene: CHML

Molecular Weight: 85 kDa

Gene ID: 1122

UniProt: P26374