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Actin-Like 6B antibody (Internal Region)

ACTL6B Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6259751
  • Target See all Actin-Like 6B (ACTL6B) Antibodies
    Actin-Like 6B (ACTL6B)
    Binding Specificity
    • 8
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 32
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 32
    • 1
    Rabbit
    Clonality
    • 32
    • 1
    Polyclonal
    Conjugate
    • 16
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Actin-Like 6B antibody is un-conjugated
    Application
    • 26
    • 19
    • 16
    • 13
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    ACTL6B Antibody detects endogenous levels of total ACTL6B.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human ACTL6B, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product ACTL6B Primary Antibody
  • Application Notes
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    Actin-Like 6B (ACTL6B)
    Alternative Name
    ACTL6B (ACTL6B Products)
    Synonyms
    MGC110167 antibody, zgc:110167 antibody, ACTL6 antibody, BAF53B antibody, Actl6 antibody, ArpNa antibody, Baf53b antibody, actin-like 6B antibody, actin like 6B antibody, actl6b antibody, ACTL6B antibody, Actl6b antibody
    Background

    Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).

    Gene: ACTL6B

    Molecular Weight
    47 kDa
    Gene ID
    51412
    UniProt
    O94805
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