ADAM15 antibody (Internal Region)

Catalog No. ABIN6259768

Product Details anti-ADAM15 Antibody

Target: ADAM15 (ADAM Metallopeptidase Domain 15 (ADAM15))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM15 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: ADAM15 Antibody detects endogenous levels of total ADAM15.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ADAM15, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ADAM15

Target: ADAM15 (ADAM Metallopeptidase Domain 15 (ADAM15))

Alternative Name: ADAM15 (ADAM15 Products)

Synonyms: ADAM15 antibody, mdc15 antibody, MDC15 antibody, metargidin antibody, tMDCVI antibody, ADAM metallopeptidase domain 15 antibody, ADAM metallopeptidase domain 15 L homeolog antibody, a disintegrin and metallopeptidase domain 15 (metargidin) antibody, ADAM15 antibody, adam15.L antibody, adam15 antibody, Adam15 antibody

Background:

Description: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

Gene: ADAM15

Molecular Weight: 93 kDa

Gene ID: 8751

UniProt: Q13444