ALKBH7 antibody
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- Target See all ALKBH7 Antibodies
- ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ALKBH7 antibody is un-conjugated
- Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- ALKBH7 Antibody detects endogenous levels of total ALKBH7
- Cross-Reactivity
- Human, Mouse (Murine)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ALKBH7
- Isotype
- IgG
- Top Product
- Discover our top product ALKBH7 Primary Antibody
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anti-AlkB, Alkylation Repair Homolog 7 (ALKBH7) (AA 1-221) antibody
ALKBH7 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:1000-3000 IHC 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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- Target
- ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
- Alternative Name
- ALKBH7 (ALKBH7 Products)
- Synonyms
- ABH7 antibody, SPATA11 antibody, UNQ6002 antibody, 2310045B01Rik antibody, 2510008E23Rik antibody, Abh7 antibody, Spata11 antibody, alkB homolog 7 antibody, Alkbh7 antibody, ALKBH7 antibody
- Background
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Description: May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
Gene: ALKBH7
- Molecular Weight
- 24 kDa
- Gene ID
- 84266
- UniProt
- Q9BT30
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