BVES antibody (Internal Region)

Catalog No. ABIN6260332

Product Details anti-BVES Antibody

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BVES antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: BVES Antibody detects endogenous levels of total BVES.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BVES, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for BVES

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Alternative Name: BVES (BVES Products)

Synonyms: HBVES antibody, POP1 antibody, POPDC1 antibody, Pop1 antibody, Popdc1 antibody, mBVES antibody, Popeye-1 antibody, Xbves antibody, Xbves-A antibody, Xpop-1 antibody, Xpop-1-A antibody, pop-1 antibody, pop1 antibody, pop1-A antibody, popdc1 antibody, popdc1-A antibody, zgc:86887 antibody, BVES antibody, Xpop-1-B antibody, bves antibody, pop1-B antibody, popdc1-B antibody, hbves antibody, blood vessel epicardial substance antibody, blood vessel epicardial substance L homeolog antibody, blood vessel epicardial substance S homeolog antibody, BVES antibody, Bves antibody, bves.L antibody, bves antibody, bves.S antibody

Background:

Description: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca2+-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.

Gene: BVES

Molecular Weight: 41kDa

Gene ID: 11149

UniProt: Q8NE79