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CBX2 antibody (Internal Region)

CBX2 Reactivity: Human, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6260519
  • Target See all CBX2 Antibodies
    CBX2 (Chromobox Homolog 2 (CBX2))
    Binding Specificity
    • 11
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 61
    • 22
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Mouse
    Host
    • 54
    • 6
    • 1
    Rabbit
    Clonality
    • 52
    • 8
    • 1
    Polyclonal
    Conjugate
    • 29
    • 6
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CBX2 antibody is un-conjugated
    Application
    • 43
    • 39
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    CBX2 Antibody detects endogenous levels of total CBX2.
    Predicted Reactivity
    Pig,Bovine,Sheep,Rabbit
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CBX2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CBX2 Primary Antibody
  • Application Notes
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    CBX2 (Chromobox Homolog 2 (CBX2))
    Alternative Name
    CBX2 (CBX2 Products)
    Synonyms
    cbx2 antibody, M33 antibody, pc1 antibody, wu:fd20e09 antibody, zgc:103563 antibody, MOD2 antibody, pc antibody, CDCA6 antibody, SRXY5 antibody, cdca6 antibody, m33 antibody, chromobox 2 antibody, chromobox homolog 2 (Drosophila Pc class) antibody, chromobox 2 L homeolog antibody, cbx2 antibody, CBX2 antibody, Cbx2 antibody, cbx2.L antibody
    Background

    Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).

    Gene: CBX2

    Molecular Weight
    56 kDa
    Gene ID
    84733
    UniProt
    Q14781
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